Profiling Patients

This project is focused on establishing the feasibility of using a metabolomic approach in patients undergoing androgen deprivation to identify serum markers of tissue androgen effect and risks of adverse metabolic outcomes.  This work is leading toward the delineation of the cellular mechanisms by which prostate tumors maintain or ‘buffer’ intratumoral androgen levels in the castrate microenvironment and the evaluation of the pre-clinical efficacy of novel agents targeting these pathways.