Slowing Cell Growth

Suppressing the hormone testosterone is currently the most effective treatment for advanced prostate cancer. However, tumors frequently develop resistance to this therapy. We are testing the hypothesis that complete inhibition of testicular, adrenal, and intraprostatic androgen production will be necessary to achieve maximal suppression of intra-prostatic androgen levels and maximal tumor cell apoptosis and growth inhibition in a clinical study of neoadjuvant androgen suppression prior to prostatectomy.